Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood 1,2,3,4,5,6,7,8,9,10. Here we report that ...

The etiology of schizophrenia (SCZ) is multifactorial, and depending on a host of genetic and environmental factors. Two putative SCZ susceptibility genes, Disrupted-in-Schizophrenia-1 (DISC1) and ...

Here we report the protein expression of DISC1 in autopsied human brains, especially brains from patients with major mental illnesses. Changes in the subcellular distribution of a form of DISC1, which ...

Universität Jena, Institut für Allgemeine Zoologie und Tierphysiologie, Jena, Germany Animals used were timed pregnant C57BL/6 mice. The day of insemination was considered as embryonic day (E) 1. Mice ...

Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a ...

Many genetic studies have indicated that DISC1 is not merely "disrupted-in-schizophrenia," but is more generally implicated in various brain dysfunctions associated with aberrant neurodevelopment and ...

Disrupted-In-Schizophrenia-1 (DISC1) is a strong genetic risk factor associated with psychiatric disorders. Two distinct mutations in the second exon of the DISC1 gene (Q31L and L100P) lead to either ...