The addition of hormone therapy to radiotherapy improves overall survival in men with high-risk prostate cancer, over radiotherapy alone.1 Mechanisms proposed to explain this effect include ...

Clinicians frequently rely on expert opinions, which are sometimes later disproven by randomised controlled trials (RCTs).

GLP-1 receptor agonists have largely contributed to revolutionising pharmacological therapy of type 2 diabetes. They are among the most potent glucose-lowering agents, while also eliciting bodyweight ...

As the population ages, China will face an ever-increasing burden from CS. Strategies targeting elder population and high-risk groups should be prioritized in the establishment of management related ...

US President's Emergency Plan for AIDS Relief (PEPFAR), the global HIV response has entered a second year of structural ...

This issue of the journal features a Series of three papers on artificial intelligence (AI) in infectious diseases. The Series, led by Anna Odone (University of Pavia, Italy) and published online in ...

The weaponisation of restricting digital connectivity has been increasingly normalised. In 2024, governments imposed 296 internet shutdowns across 54 countries, with at least 72 directly linked to ...

In paediatrics, “more trials have been done over the last ten years, but we have struggled with transparency and clarity, and sometimes with the quality because they are not always asking the ...

Early clinical trials established the safety and feasibility of closed-loop insulin delivery, but the 2019 iDCL trial1 marked the first large, outpatient, randomised, controlled trial to show a ...

Mark Butler's involvement in health long predates his time in Australia's Parliament; he was a lawyer for and later led United Voice, an Australian health workers' union. He also worked in personal ...

Russia's full-scale invasion of Ukraine has been a catastrophe on every level, not least for health. 4 years on, there have been more than 47 000 Ukrainian civilian casualties. 5·6 million people have ...

Much uncertainty remains in the evidence base for child and adolescent health. Not only is the quality of clinical trials ...